Agonising death of Oxford cancer victim

Quoted from http://www.oxfordtimes.co.uk/news/8790507.Agonising_death_of_Oxford_cancer_victim/

Agonising death of Oxford cancer victim

9:30am Friday 14th January 2011

A HOSPITAL last night pledged to make changes to drug trials after an Oxford cancer sufferer endured an “unimaginable nightmare” and died while testing a new treatment.

Andy Witney died in August last year after a five-year cancer battle, but an inquest in Oxford heard yesterday the trial drugs may have accelerated his death.

The 56-year-old suffered from mesothelioma, an incurable cancer caused by exposure to asbestos. The former Cowley car worker had been a “human guinea pig” taking part in cancer drug trials at the Churchill Hospital in Oxford.

But severe side effects left him in agony, without the use of his lower legs and suffering uncontrollable diarrhoea. He died 12 days later.

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Malignant Mesothelioma — Many Hidden Cases

Quoted from http://www.medscape.com/viewarticle/735359

Malignant Mesothelioma — Many Hidden Cases

Zosia Chustecka

January 6, 2011 — Cases of malignant mesothelioma, caused almost exclusively by exposure to asbestos, are significantly underreported worldwide, concludes a new study published online January 6 in Environmental Health Perspectives.

This study is the first to provide a global estimate of unreported cases. Many underdeveloped countries do not report mesothelioma, despite extensive use of asbestos. Because there is a direct link between the 2, the study authors used data from countries that do report mesothelioma to extrapolate to the countries that do not. Their conclusion: for every 4 to 5 reported cases of mesothelioma worldwide, at least 1 case goes unreported.

“Our most important finding is the magnitude of unreported mesothelioma in countries that use asbestos at substantial levels but report no cases of the disease,” study coauthor Ken Takahashi, MD, from the University of Occupation and Environmental Health, Kitakyushu City, Japan, said in a statement. Such countries include Russia, Kazakhstan, China, and India, which all rank in the top 15 countries for cumulative asbestos use.

The authors propose a worldwide ban on the mining, use, and export of asbestos, because eliminating exposure to asbestos would prevent mesothelioma.

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Mesothelioma: The environmental cancer that strikes on the job

Quoted from http://www.nydailynews.com/lifestyle/health/2010/10/20/2010-10-20_mesothelioma_the_environmental_cancer_that_strikes_on_the_job.html

Mesothelioma: The environmental cancer that strikes on the job

By Katie Charles
DAILY CHECKUP

Wednesday, October 20th 2010, 4:00 AM

As a professor and chief of thoracic surgery at Mount Sinai Hospital, Raja Flores operates on cancers of the chest, mostly lung and esophageal cancer. Over the past 15 years, he has specialized in mesothelioma and sees more than 50 cases annually.

Who’s at risk

Mesothelioma is a relatively rare cancer that affects about 3,000 Americans a year. “Mesothelioma is a cancer of the lining of the lung,” says Flores. “It starts in one spot, creeps throughout the chest and can give a slow, painful death.”

According to the National Cancer Institute, the incidence of mesothelioma has increased during the past 20 years. Environmental exposures account for the vast majority of patients.

“Asbestos exposure is the No. 1 risk factor,” says Flores. “That refers to naturally occurring minerals present in many industrial products, like cement, textiles and insulation.”

Asbestos can become dangerous when inhaled or swallowed, often during manufacturing. Most sufferers of the disease had exposure to asbestos on the job, where it is a risk for workers like insulators, rescue teams (such as after 9/11) and shipyard crews.

One challenge in fighting mesothelioma is that asbestos exposure is often silent and invisible. “Many people don’t even know they’ve been exposed,” says Flores. “There can be a 20- to 30-year latency, so it’s years after they’re exposed that they see symptoms.”

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Tests may detect mesothelioma, pancreatic cancer

Quoted from http://www.reuters.com/article/idUSTRE68R5T220100928

Tests may detect mesothelioma, pancreatic cancer

By Julie Steenhuysen

CHICAGO | Tue Sep 28, 2010 5:28pm EDT

CHICAGO (Reuters) – U.S. researchers have discovered specific changes in the blood of patients with two deadly cancers that may allow doctors to diagnose them at an earlier stage.

Using new screening technology developed by privately held Somalogic Inc, company researchers said on Tuesday they could detect early signs of pancreatic cancer and a type of lung cancer called mesothelioma in people who had been diagnosed but not treated for the diseases.

“Currently these cancers are detected at an advanced stage, where the possibility of cure is minimal,” said Rachel Ostroff, clinical research director of Somalogic Inc, who presented the findings on Tuesday at an American Association for Cancer Research meeting in Denver.

“Detection of these aggressive cancers at an earlier stage would identify patients for early treatment, which may improve their survival and quality of life.”

Pancreatic cancer is relatively rare, but it is the fourth-leading cause of cancer-related death in the United States. Mesothelioma, caused by asbestos, kills an estimated 15,000 to 20,000 people per year worldwide.

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Australian warns against asbestos

Quoted from http://www.itwire.com/science-news/health/41198-australian-warns-against-asbestos


Australian warns against asbestos

By William Atkins
Monday, 16 August 2010

Dr. Peter Sly, an expert in asbestos, warns the world that asbestos is still a major problem in developing countries. Although banned in 52 countries, its use is prevalent in many other countries–making it a hazardous substance for millions of people. 

Dr. Peter D. Sly founded the Division of Clinical Sciences at the Queensland Children’s Medical Research Institute, which is located at the University of Queensland.

The professor states that over two million tonnes of asbestos were produced around the world in 2008 even though there is an international effort to ban such practices.

In the Sydney Morning Herald article “Asbestos still a global threat” Dr. Sly states, “Developing countries, especially in Asia and Eastern Europe, are mining or importing asbestos for domestic use, and now account for the majority of the world’s exposure to asbestos.”

The quote came from his paper, which was published on August 16, 2010, in the Medical Journal of Australia.

The paper is entitled “Asbestos still poses a threat to global health: now is the time for action (MJA 2010; 193 (4): 198-199).

Besides Dr. Sly, its authors are Robin Chase, John Kolbe, Philip Thompson, Leena Gupta, Mike Daube, Ian Olver, and Deborah Vallance.

The abstract to the paper states, “The adverse health effects of asbestos are well known, with all forms of asbestos recognised as human carcinogens, causing malignant mesothelioma, lung, laryngeal and ovarian cancers as well as the debilitating non-malignant diffuse lung disease, asbestosis, and pleural plaques.”

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Asbestosis: 2010 Update: eMedicine Pulmonology

Quoted from http://emedicine.medscape.com/article/295966-overview

Asbestosis

eMedicine Specialties > Pulmonology > Occupational Lung Diseases

Introduction

Background

Pneumoconiosis is the general term for lung disease caused by inhalation and deposition of mineral dust.

Pneumoconiosis caused by asbestos inhalation is called asbestosis. The word asbestos is derived from Greek and means inextinguishable, and asbestos is a group of naturally occurring, heat-resistant fibrous silicates. Asbestos fibers are long and thin (length-to-diameter ratio >3) and may be either curved or straight. The curved fibers are called serpentine (chrysotile is the prime example), and the straight fibers are amphiboles. Several different types of amphiboles (ie, amosite, anthophyllite, tremolite, actinolite, crocidolite) have been recognized. Chrysotile is by far the most common type of asbestos fiber produced in the world and accounts for virtually all asbestos used commercially in the United States.

Production and use of asbestos increased greatly between 1877 and 1967. In the 1930s and 1940s, scientists recognized a causal link between asbestos exposure and asbestosis. In the 1950s and 1960s, researchers established asbestos as a predisposing factor for bronchogenic carcinoma and malignant mesothelioma.

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Order Tossing Expert Grabs Attention in Asbestos Case

Quoted from http://www.law.com/jsp/article.jsp?id=1202464446271

Order Tossing Expert Grabs Attention in Asbestos Case

Katheryn Hayes Tucker

Fulton County Daily Report

August 11, 2010

Orders from a middle Georgia judge throwing out an expert witness and the asbestos suit his testimony was going to support have defense attorneys celebrating and plaintiffs lawyers bearing down for an appellate battle.

At issue is a June 29 decision by Ocmulgee Judicial Circuit Superior Court Judge John Lee Parrott. He barred the testimony of John Maddox, a pathologist who claims that asbestos caused the lung disease that killed the plaintiff’s husband.

The problem, Parrott said, is the doctor’s opinion that any exposure to asbestos causes injury. That opinion, the judge said, “is not practically testable and has not been tested,” thereby violating one of the prongs of Georgia’s 2005 law governing the use of expert witnesses.

The law, based on the U.S. Supreme Court’s 1993 Daubert v. Merrell Dow Pharmaceuticals decision, 509 U.S. 579, says that expert witnesses may be barred from testifying if their theories or techniques cannot be tested.

“[T]he courtroom is not the place for scientific guesswork, even of the inspired sort,” Parrott wrote, quoting a 1996 decision from the 7th U.S. Circuit Court of Appeals.

Lawyers who defend companies from asbestos cases hailed Parrott’s decision as great news and predicted it could influence other judges around the state.

Lawyers for asbestos plaintiffs dismissed the ruling.

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Malignant Mesothelioma: Overview Guide

Quoted from https://www.cancer.org/Cancer/MalignantMesothelioma/OverviewGuide/index

Malignant Mesothelioma Overview

 

What Is Malignant Mesothelioma?

Causes, Risk Factors, and Prevention

Early Detection, Diagnosis, and Staging

Treating Malignant Mesothelioma

Talking With Your Doctor

After Treatment

What`s New in Malignant Mesothelioma Research?

Other Resources and References

Malignant Mesothelioma: Detailed Guide

Quoted from https://www.cancer.org/Cancer/MalignantMesothelioma/DetailedGuide/index

Malignant Mesothelioma

 

What Is Malignant Mesothelioma?

Causes, Risk Factors, and Prevention

Early Detection, Diagnosis, and Staging

Treating Malignant Mesothelioma

Talking With Your Doctor

After Treatment

What`s New in Malignant Mesothelioma Research?

Other Resources and References

Australian breakthrough may help lung disease patients

Quoted from http://www.abc.net.au/am/content/2010/s2929158.htm

Australian breakthrough may help lung disease patients

Sarah Gerathy reported this story on Thursday, June 17, 2010 08:09:00

 

TONY EASTLEY: Australian scientists say they’ve made a breakthrough that could lead to new treatments for lung diseases like emphysema, asbestosis and severe asthma.

They’ve discovered that a type of cell found in human placentas can reduce inflammation and scarring to the lungs.

The team from the Lung Institute of Western Australia and the Monash Institute of Medical Research has successfully tested the treatment on mice and are now planning to conduct trials on human tissue.

They’ve published their findings in this month’s issue of the American Journal of Respiratory and Critical Care Medicine.

Sarah Gerathy spoke to the study’s lead researcher, Associate Professor Yuben Moodley.

YUBEN MOODLEY: What we found is that in the human placenta there are cells that develop from the embryo, that are not part of the embryo, that are then passed into the placenta and form part of the placenta. These cells seem to have properties whereby they can differentiate into lung cells, not completely but show that type of property or phenotype.

SARAH GERATHY: And I understand you’ve now successfully tested the cell on mice, so can you tell us a little bit about that? 


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